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Chondroitin – ny forskning
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 Chondroitin sulfat i præparatet Chondro-Lenk er et større sukkermolekyl, som udvindes fra oksebrusk, og består af repeterede enheder af galactosamin og glucuronsyre, men med betydelig variation både i struktur og størrelse (25-40 kDa).
Et studie med raske frivillige og personer med artrose viser, at også chondroitin sulfat absorberes fra tarmen.
Chondroitin har en gunstig effekt på smerte og funktion, som kan observeres efter 1-2 måneders behandling. Kombineret effekt-estimat i forhold til placebo:
Chondroitin:
Funktion-smerte: 0,33 (95% CI 0,13-0,53), p=0.002.
Læs mere om Chondro-Lenk her!
Referencer:
Conte A, Volpi N, Pahnieri L, Bahous I, Ronca G.: Biochemical and pharmacokinetic aspects of oral treatment with chondroitin sulfate. Arzneimittelforschung 1995;45(8):918-925.
Bourgeois P, Chales G, Dehais J, Delcambre B, Kuntz JL, Rozenberg S.: Efficacy and tolerability of chondroitin sulfate 1200 mg/day vs chondroitin sulfate 3 x 400 mg/day vs placebo. Osteoarthritis Cartilage 1998; 6 Suppl A:25-30.
European multicenter study on effectiveness of chondroitin sulfate in gonarthrosis: a new look at biochemical and radiologic results. Presse Med 2000; 29(27 Suppl):15-18.
Bucsi L, Poor G.: Efficacy and tolerability of oral chondroitin sulfate as a symptomatic slow-acting drug for osteoarthritis (SYSADOA) in the treatment of knee osteoarthritiis. Osteoarthritis Cartilage 1998; 6 Suppl A:31-36.
Mathieu P.: Radiological progression of internal femoro-tibial osteoartbritis in gonarthrosis. Chondro-protective effect of kondmitin sulfates ACS4-ACS6. Presse Med 2002, 31(29):1386-1390.
Mazieres B, Loyau G, Menkes CJ, Valat JP, Dreiser RL, Charlot J et al.: Chondroitin sulfate in the treatment of gonarthrosis and coxarthrosis. 5-months result of a multicenter double-blind controlled prospective study using placebo. Rev Rhum Mal Osteoartic 1992; 59(7-8):466-472.
Mazieres B, Combe B, Phan VP., Tondut J, Grynfeltt M.: Kondroitin sulfate in osteoarthritis of the knee: a prospective, double blind, placebo controlled multicenter clinical study. J Rheumatol 2001; 28(1):173-181.
Uebelhart D, Thonar EJ, Delmas PD, Chantraine A, Vignon E.: Effects of oral chondroitin sulfate on the progression of knee osteoarthritis: a pilot study. Osteoarthritis Cartilage 1998; 6 Suppl. A: 39-06.
Morreale P, Manopulo R, Galati M, Boccanera L, Saponati G, Bocchi L.: Comparison of the antiinflammatory efficacy of kondroitin sulfate and diclofenac sodium in patients with knee osteoarthritis. J Rheumatol 1996; 23(8):1385-1391.
McNamara PS, Barr SC, Erb HN.: Hematologic, hemostatic, and biochemical effects in dogs receiving an oral chondroprotective agent for thirty days. Am J Vet Res 1996; 57(9):1390-1394.
Health News 2004
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